Solid oral administration for deworming—leading the way to healthy livestock farming!

Release time： 2021-03-29

【Summary Description】 Have you ever heard of a water-soluble oral administration deworming regimen? You might have heard of oral administration formulations in liquid form, such as ivermectin solution and doramectin solution. But I’m sure you’ve never heard of solid, water-soluble oral dewormers—absolutely not of a water-soluble solid dewormer based on moxidectin. However, the upgraded Moxi-Par from Dutch Hylife has made it possible. The advantages of water-soluble solid dewormers. Compared to liquid formulations, solid water-soluble dewormers offer three major advantages: First, solid dewormers are more stable; liquid formulations tend to undergo chemical reactions and oxidation over time, reducing their efficacy. Second, liquid formulations often use organic solvents as their carriers. During production and application, oil-based solvents mixed with water easily separate into layers, making it difficult to achieve uniformity. Third, solid dewormers are easier to transport and store. The process standards for water-soluble Moxi-Par. Hylife has established stringent process standards, specifically: 1. The formulation completely mimics on-site administration methods: It should dissolve quickly in plain water at 0°C with simple stirring or by pouring water for just 10 seconds. After standing for 8 hours, a 2% aqueous solution should show no discoloration, no precipitation, no turbidity, no floating particles, and no unusual odor. 2. After standing for 8 hours, the effective drug content in the upper, middle, and lower layers of the 2% aqueous solution must reach over 90% of the theoretical value, and the deviation between the three layers’ drug contents should be less than 2.5%. 3. The solvent, carrier, and active ingredients must not undergo any chemical reactions, ensuring safety and non-toxicity. How was the water-soluble solid Moxi-Par developed? Relying on the strong R&D team from the Technology Department of Dutch Hylife International Co., Ltd. (animal health products), the Technology Department of Hunan Hylife Animal Health Products Co., Ltd. spent two years completing the product upgrade. The core process principle is as follows: The liposoluble dewormer moxidectin is air-milled to 600 mesh, transforming large-molecule drugs into nano-sized small molecules; then uniformly cold-sprayed into a specialized solvent system (composed of wetting agents, surfactants, dispersants, pH adjusters, and ion adsorbents) to create a soluble raw material; finally, it’s pre-mixed in graded portions with a specially formulated water-soluble carrier. The advantages of water-soluble solid Moxi-Par. Product Features Impact on Results High safety. Several times safer than the second-generation ivermectin premix. Usable throughout all stages, enabling simultaneous deworming of the entire herd, with virtually zero toxic reactions such as abortion, reduced sperm quality, loss of appetite, or death. Long-lasting effect. Half-life up to 21 days. Covers the entire life cycle of parasites, even killing larvae and adult worms from 2 to 5 generations. High drug concentration in subcutaneous fat. It’s the dewormer with the highest fat concentration. Efficient against external parasites like ticks, mites, and lice. Broad-spectrum and highly effective. Can eliminate 95% of both internal and external parasites. Uniform dosing, high drug intake coefficient. Lengthens the interval between dewormings, reducing the number of deworming treatments per year by 1–2 times. Simple operation, easy to use. Saves labor, reduces energy consumption, and boosts economic value. Usage guidelines for water-soluble solid Moxi-Par. 1. Mixing method: Add 1 kg per ton of feed evenly, use continuously for 7–14 days. 2. Drinking-water method (first measure the quantity, then dissolve in water; the drug concentration should not exceed 2%, meaning no more than 2 kg of Moxi-Par per 100 kg of water): By body weight: For pigs weighing 2,000–2,500 kg, add 100 g of this product; dissolve in water and administer in one dose or drink within half a day; use continuously for 7–14 days. By feed quantity: Add 0.1% of this product to the total daily feed amount for the entire pig herd. Dissolve in water and administer in one dose or drink within half a day; use continuously for 7–14 days. Proven effectiveness of Moxi-Par. Moxi-Par is highly effective against external parasites such as ticks, mites, and lice, as well as internal parasites including roundworms, capillaria, Onchocerca volvulus, Strongyloides, hookworms, whipworms, pinworms, and lungworms. If no adult worms or larvae are observed after using Moxi-Par according to the recommended guidelines, the only conclusion is that there are no parasites present—this can be confirmed through egg testing. The impact of water-soluble solid Moxi-Par on sales and customer acquisition. It effectively expands new customer bases in the following areas: Farming groups using pellet feed; Farming groups using automated feeding systems; Mountain cattle and sheep farms, and special breeding operations in forested areas; Young farmers. In summary, Water-soluble solid Moxi-Par boasts clear advantages in terms of high efficiency, safety, long-lasting effect, convenience, and novelty, continuously creating value for customers and users. By focusing on product quality, the solid water-dissolving administration method is becoming a new trend in deworming, leading a new revolution in healthy animal husbandry.

Have you heard of the water-soluble oral administration deworming method?

You’ve probably heard of oral administration of solution-based formulations, such as ivermectin solution and doramectin solution. But I’m sure you’ve never heard of solid, water-soluble oral anthelmintics. And you’ve certainly never heard of a water-soluble solid anthelmintic based on moxidectin. The upgraded version of Moxidectin from the Dutch company Ceva has made this possible.

Advantages of water-soluble solid insecticides.

Compared to liquid formulations, solid water-soluble insecticides have three major advantages:

1. Solid insecticidal formulations are more stable; solution formulations, when left standing for an extended period, are prone to chemical reactions and oxidation, which can reduce their efficacy.

2. The solvents used in solution preparations are mostly organic solvents. When applied in production, oil-based solvents mixed with water tend to separate into layers, making it difficult to achieve a high degree of uniformity.

3. Solid insecticides are easier to transport and store.

Process standards for water-soluble moxidectin.

Xilai Gao has established stringent process standards, specifically:

1. Completely replicate the on-site administration method: The product must dissolve rapidly within 10 seconds when simply stirred or rinsed with water at 0°C; after standing for 8 hours in a 2% aqueous solution, it should show no discoloration, no precipitation, no turbidity, no floating particles, and no unusual odor.

2 After standing for 8 hours, the effective drug content in the upper, middle, and lower layers of the 2% aqueous solution reached over 90% of the theoretical value, and the deviation in drug content among the three layers was minimal. < 2.5% 。

3 The solvent, carrier, and main ingredient do not undergo any chemical reactions and are safe and non-toxic.

How was the solid water-soluble formulation of moxifloxacin developed?

Relying on the powerful R&D team from the Technology Department of Holland Hailigao (Animal Health Products) International Co., Ltd., the Technology Department of Hunan Hailigao Animal Health Products Co., Ltd. spent two years completing the product upgrade. The core technological principle involves air-flow grinding the liposoluble anthelmintic moxidectin to a particle size of 600 mesh, transforming it from a macromolecular drug into a nano-sized small-molecule drug. This finely ground material is then uniformly cold-sprayed into a specialized solvent system—composed of a wetting agent, surfactant, dispersant, pH adjuster, and ion adsorbent—to produce a soluble raw material. Finally, this soluble raw material is pre-mixed in graded stages with a specially formulated water-soluble carrier to obtain the final product.

The advantages of MosiGuard solid water-soluble formulation.

Product Features	Impact on the results
High safety. Several times safer than the second-generation ivermectin premix.	It can be used throughout all stages, ensuring uniform treatment across the entire herd. Toxic reactions such as abortion, oligospermia, loss of appetite, and mortality are virtually nonexistent.
Long-lasting. With a half-life of up to 21 days.	Covers the entire life cycle of parasites, even killing 2–5 generations of larvae and adult worms.
The drug concentration in subcutaneous fat is high. It is the anthelmintic with the highest drug concentration in fat.	Highly effective against external parasites such as ticks, mites, and lice.
Broad insecticidal spectrum, highly effective	Can kill 95% of parasites both inside and outside the body.
Uniform drug administration with a high drug absorption coefficient.	Extend the interval between deworming treatments, reducing the number of deworming sessions per year by 1-2 times.
Simple to operate and convenient to use.	Save labor, reduce energy consumption, and enhance economic value.

Usage protocol for Mosquito Control Solid Water-Soluble Agent.

1 Mixing Method: Add 1 kg per ton of feed evenly, and use continuously for 7–14 days.

2 Drinking Water Method (First measure the required amount of water, then dissolve the medication; the drug concentration should not exceed 2%, meaning no more than 2 kg of moxidectin per 100 kg of water):

By body weight quantification: For pigs weighing 2000–2500 kg, add 100 g of this product; dissolve it in water and administer it all at once or drink it within half a day; use continuously for 7–14 days.
Quantitative Feeding Method: Add 0.1% of this product to the total daily feed amount for the entire pig herd. Dissolve it in water and administer it all at once, or ensure it is consumed within half a day; use continuously for 7–14 days.

The empirical effects of moxifloxacin.

Moxidectin is highly effective against external parasites such as ticks, mites, and lice, as well as internal parasites including roundworms, hookworms, whipworms, filarial worms, strongyloides, trichuris, and lungworms. If no adult worms or larvae are observed after following the recommended treatment regimen, the only conclusion is that there are no parasites present; this can be confirmed through fecal egg examination.

The impact of Moxifloxacin solid water-soluble agent on sales and customer acquisition.

Effectively expand new customer sources in the following areas:

Aquaculture populations using pellet feed;
Use automated feeding lines to raise large-scale livestock populations;
Mountain cattle and sheep, as well as specialized livestock and poultry farming groups in mountainous and forested areas;
Young people involved in animal husbandry.

Summary

Moxidectin solid water-soluble formulation boasts distinct advantages in terms of high efficacy, safety, long-lasting action, convenience, and innovation, continuously delivering value to customers and users. By focusing on product quality, the solid-water administration method for deworming is emerging as a new trend, paving the way for a transformative shift toward healthier livestock farming.

Solid oral administration for deworming—leading the way to healthy livestock farming!

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